Human NUPR1 adenoviral particles

NUPR1 (nuclear protein 1, also known as p8 or Com1) is a highly conserved, small molecule stress-induced gene that plays a key role in cellular responses to stress, inflammation, and cancer. Encoded by a single exon, NUPR1 is ubiquitously expressed and functions as a transcriptional regulator, influencing pathways associated with apoptosis, autophagy, and endoplasmic reticulum (ER) stress. Its expression is upregulated in a variety of pathological conditions, including pancreatic ductal adenocarcinoma (PDAC), liver fibrosis, and neurodegenerative diseases. NUPR1 is involved in tumor progression, metastasis, and chemoresistance, making it a promising target for therapeutic intervention.

Human NUPR1 Adenoviral Particles are genetically engineered viral vectors designed to deliver the NUPR1 gene to target cells for functional studies or therapeutic applications. These particles are based on a replication-defective adenovirus, which ensures efficient transduction into a variety of dividing and non-dividing cells while minimizing cytotoxicity. This adenoviral system has high transduction efficiency and stable transgene expression, making it ideal for in vitro and in vivo studies. They are particularly valuable in cancer research, as the dual role of NUPR1 as a stress adaptor and oncogenic driver requires precise manipulation. In addition, these particles are routinely purified and titrated to ensure consistency in experimental results, supporting applications in gene therapy development and mechanistic studies.