This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene.
Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem;
DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; damaged DNA binding; hydrolase activity, acting on glycosyl bonds; lyase activity; protein C-terminus binding; zinc ion binding;