Human NEIL1 Knockdown Cell Line-HeLa

Name: Human NEIL1 Knockdown Cell Line-HeLa
SKU: CSC-RK0037
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0037

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0037
Background	This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene.
Target Gene	NEIL1
Abbr	HeLa-HuNEIL1 Knockdown
Alias	NEIL1, FLJ22402, FPG1, hFPG1, NEI1, NEH1
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	NEIL1 nei endonuclease VIII-like 1 (E. coli) [ Homo sapiens ]
Gene Symbol	NEIL1
Synonyms	NEIL1; nei endonuclease VIII-like 1 (E. coli); endonuclease 8-like 1; FLJ22402; FPG1; hFPG1; NEI1; NEH1; nei homolog 1; endonuclease VIII; nei-like protein 1; endonuclease VIII-like 1; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1;
GeneID	79661
Uni ProtID	Q96FI4
mRNA Refseq	BC010876
Chromosome Location	15q33.33
Function	DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; damaged DNA binding; hydrolase activity, acting on glycosyl bonds; lyase activity; protein C-terminus binding; zinc ion binding;
Pathway	Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem;
MIM	608844

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