Creative biogene
SHARE THIS
facebook twitterlinkedingoogle plusStumbleUpon blog


Human MSH6 Knockdown Cell Line-LN428 Glioma

See other products for MSH6
Cat.No.
CSC-RK0237
Background
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
MSH6
Synonyms
MSH6; mutS homolog 6 (E. coli); GTBP, mutS (E. coli) homolog 6; DNA mismatch repair protein Msh6; p160; GTMBP; hMSH6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein; GTBP; HSAP; HNPCC5;
Gene ID
MIM
UniProt ID
P52701
Chromosome Location
2p16
Pathway
BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Mismatch repair, organism-specific biosystem; Mismatch repair, conserved biosystem; Pathways in cancer, organism-specific biosystem;
Function
contributes_to ADP binding; contributes_to ATP binding; contributes_to ATPase activity; DNA-dependent ATPase activity; contributes_to MutLalpha complex binding; chromatin binding; damaged DNA binding; contributes_to double-stranded DNA binding; contributes_to four-way junction DNA binding; contributes_to guanine/thymine mispair binding; contributes_to magnesium ion binding; contributes_to mismatched DNA binding; nucleotide binding; contributes_to oxidized purine DNA binding; protein binding; contributes_to protein binding; NOT protein homodimerization activity; contributes_to single guanine insertion binding; contributes_to single thymine insertion binding;
Related Products
Cat#
Product Name
Host Cell
Gene Symbol
Species
Price
CSC-SC009823
HEK293 ,CHO, etc.
MSH6
Human
CSC-DC009823
HEK293 ,Hela, etc.
MSH6
Human
CSC-RT0501
HeLa
MSH6
------
Cat#
Product Name
Titer
Product Size
Species
Price
LV00380Z
10^7 - 10^9 copies/ml
200 ul
Human
AD10240Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human
Cat#
Product Name
Size/Form
Species
Price
CDCB177010
------
Danio rerio (zebrafish)
SHW015535
------
Danio rerio (zebrafish)

Related Services

Quick Inquiry

Please input "biogene" as verification code.

CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

Terms & Conditions | Privacy Policy | Sitemap | FAQ | © 2010-2018 Creative Biogene. All Rights Reserved.