Human MSH6 Knockdown Cell Line - Glioma

Name: Human MSH6 Knockdown Cell Line - Glioma
SKU: CSC-RK0237
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0237

Host Cell : Glioma Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0237
Description	This cell line is engineered to stably express shRNA targeting human MSH6.
Target Gene	MSH6
Host Cell	Glioma
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Storage	Liquid nitrogen
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	MSH6 mutS homolog 6 (E. coli) [ Homo sapiens ]
Gene Symbol	MSH6
Synonyms	MSH6; mutS homolog 6 (E. coli); GTBP, mutS (E. coli) homolog 6; DNA mismatch repair protein Msh6; p160; GTMBP; hMSH6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein; GTBP; HSAP; HNPCC5;
GeneID	2956
Uni ProtID	P52701
mRNA Refseq	BC004246
Chromosome Location	2p16
Function	contributes_to ADP binding; contributes_to ATP binding; contributes_to ATPase activity; DNA-dependent ATPase activity; contributes_to MutLalpha complex binding; chromatin binding; damaged DNA binding; contributes_to double-stranded DNA binding; contributes_to four-way junction DNA binding; contributes_to guanine/thymine mispair binding; contributes_to magnesium ion binding; contributes_to mismatched DNA binding; nucleotide binding; contributes_to oxidized purine DNA binding; protein binding; contributes_to protein binding; NOT protein homodimerization activity; contributes_to single guanine insertion binding; contributes_to single thymine insertion binding;
Pathway	BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Mismatch repair, organism-specific biosystem; Mismatch repair, conserved biosystem; Pathways in cancer, organism-specific biosystem;
MIM	600678

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