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Human MSH5 Knockdown Cell Line-LN428 Glioma

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Cat.No.
CSC-RK0236
Background
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
MSH5
Synonyms
MSH5; mutS homolog 5 (E. coli); mutS (E. coli) homolog 5; mutS protein homolog 5; G7; NG23; MUTSH5; MGC2939; DKFZp434C1615;
Gene ID
MIM
UniProt ID
O43196
Chromosome Location
6p21.3
Pathway
Meiosis, organism-specific biosystem; Meiotic Recombination, organism-specific biosystem; Ovarian Infertility Genes, organism-specific biosystem;
Function
ATP binding; DNA-dependent ATPase activity; NOT damaged DNA binding; mismatched DNA binding; mismatched DNA binding; nucleotide binding;

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