Human MAPK1 Knockdown Cell Line-HeLa

Name: Human MAPK1 Knockdown Cell Line-HeLa
SKU: CSC-RK0042
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0042

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0042
Background	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Target Gene	MAPK1
Abbr	HeLa-HuMAPK1 Knockdown
Alias	MAPK1,PRKM1, PRKM2,ERK,ERK2,MAPK2,
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	MAPK1 mitogen-activated protein kinase 1 [ Homo sapiens ]
Gene Symbol	MAPK1
Synonyms	ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk
Gene Description	mitogen-activated protein kinase 1
GeneID	5594
Uni ProtID	P28482
mRNA Refseq	NM_002745.4
Protein Refseq	NP_002736.3
Chromosome Location	22q11.21
Function	ATP binding; DNA binding; MAP kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; phosphatase binding; protein binding; protein serine/threonine kinase activity;
Pathway	ALK1 signaling events, organism-specific biosystem; ARMS-mediated activation, organism-specific biosystem; ATF-2 transcription factor network, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Activation of the AP-1 family of transcription factors, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem;
MIM	176948

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