Human LIG3 Knockdown Cell Line - Glioma

Name: Human LIG3 Knockdown Cell Line - Glioma
SKU: CSC-RK0230
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0230

Host Cell : Glioma Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RK0230
Description	This cell line is engineered to stably express shRNA targeting human LIG3.
Target Gene	LIG3
Host Cell	Glioma
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Storage	Liquid nitrogen
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	LIG3 ligase III, DNA, ATP-dependent [ Homo sapiens ]
Gene Symbol	LIG3
Synonyms	LIG3; ligase III, DNA, ATP-dependent; LIG2, ligase II, DNA, ATP dependent; DNA ligase 3; ligase II, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 3; LIG2;
Gene ID	3980
Uni Prot ID	P49916
m RNA Refseq	BC009026
Chromosome Location	17q11.2-q12
Function	ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; ligase activity; metal ion binding; nucleotide binding; protein binding; zinc ion binding;
Pathway	BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; DNA Repair, organism-specific biosystem; Resolution of AP sites via the single-nucleotide replacement pathway, organism-specific biosystem;
MIM	600940

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