Human IPO5 cDNA Clone(NM_002271.4)

Name: Human IPO5 cDNA Clone(NM_002271.4)
SKU: CDFH009327
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFH009327

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Product Information

Gene Information

Cat. No.	CDFH009327
Product Type	cDNA clone
Gene Abbr	IPO5
Species	Human
Size	10 ug
Vector	pCMV6-XL

Target Gene

IPO5

Background

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]

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