Human GSTA5 adenoviral particles

The GSTA5 gene (glutathione S-transferase α5) encodes a member of the glutathione S-transferase (GST) family, a class of enzymes that are critical for cellular detoxification and oxidative stress responses. GST catalyzes the conjugation of glutathione (GSH) to electrophilic substrates, facilitating the removal of xenobiotics, carcinogens, and reactive oxygen species (ROS). GSTA5 isoforms are primarily expressed in the liver and play important roles in metabolizing toxic compounds, protecting cells from oxidative damage, and regulating inflammatory pathways. Polymorphisms or dysregulation of GSTA5 have been associated with altered drug metabolism, susceptibility to chemical carcinogenesis, and diseases associated with oxidative stress. GSTA5 is a popular target for toxicology, pharmacology, and cancer biology studies due to its critical role in cellular defense mechanisms.

Human GSTA5 adenoviral particles are high-titer, replication-defective viral vectors designed for efficient delivery and expression of the GSTA5 gene in mammalian cells. These particles utilize an adenoviral delivery system, which is known for its high transduction efficiency in a variety of cell types, including primary cells and difficult-to-transfect cells. These particles are a valuable tool for studying the role of GSTA5 in detoxification pathways, drug resistance, and redox homeostasis. Applications include gene overexpression studies, chemoprotectant screening, and modeling of diseases associated with GST dysfunction. In addition, they have applications in gene therapy studies exploring the potential of GSTA5 to mitigate oxidative damage in diseases such as liver fibrosis or neurodegenerative diseases.