Human GNAS adenoviral particles

Name: Human GNAS adenoviral particles
SKU: AD06879Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD06879Z

Storage : -80℃ Shipping : Frozen on dry ice

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD06879Z
Description	Adenovirus with ORF of GNAS complex locus (GNAS), transcript variant 6.
Gene	GNAS
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	GNAS GNAS complex locus [ Homo sapiens ]
Gene Symbol	GNAS
Synonyms	AHO; GSA; GSP; POH; GPSA; NESP; GNAS1; PHP1A; PHP1B; PHP1C; C20orf45
Gene Description	GNAS complex locus
Gene ID	2778
Uni Prot ID	P63092
m RNA Refseq	NM_000516.4
Protein Refseq	NP_000507.1
Chromosome Location	20q13.3
Function	G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; GTPase activity; adenylate cyclase activity; ionotropic glutamate receptor binding; metal ion binding; molecular_function; mu-type opioid receptor binding; signal transducer activity; signal transducer activity;
Pathway	Alcoholism, organism-specific biosystem; Alcoholism, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Aquaporin-mediated transport, organism-specific biosystem;
MIM	139320

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