Human DUSP10 adenoviral particles

The dual-specificity phosphatase 10 (DUSP10) gene, also known as mitogen-activated protein kinase phosphatase 5 (MKP-5), encodes a member of the dual-specificity phosphatase (DUSP) family. These enzymes play a key role in cellular signaling by dephosphorylating tyrosine and serine/threonine residues on target proteins, especially mitogen-activated protein kinases (MAPKs). DUSP10 specifically inhibits MAPKs such as p38 and JNK, which play key roles in stress responses, inflammation, apoptosis, and immune regulation. By regulating MAPK activity, DUSP10 helps maintain cellular homeostasis and participates in various physiological and pathological processes, including metabolic disorders, cardiovascular diseases, and cancer. Its expression is tightly regulated and is often induced by stressors such as oxidative stress or cytokines.

Human DUSP10 adenoviral particles are recombinant viral vectors designed to deliver the DUSP10 gene to target cells for functional studies or therapeutic applications. Adenoviral systems are favored for their high transduction efficiency, ability to infect both dividing and non-dividing cells, and robust transgene expression. The particles are replication-defective, which prevents uncontrolled viral spread, ensuring safety. Researchers use DUSP10 adenoviral particles to study the role of this gene in MAPK signaling, immune regulation, or disease mechanisms. The particles are produced through cell packaging, purification, and titration to ensure consistent quality.