Human DROSHA ORF clone(NM_013235.4)

Name: Human DROSHA ORF clone(NM_013235.4)
SKU: CDCH385960
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH385960

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Product Information

Gene Information

Cat. No.	CDCH385960
Product Type	ORF clone
Gene Abbr	DROSHA
Species	Human
Host Cell	Bacterial
Source	Bacterial
Size	1ug
Format	Clear Liquid
Vector	pORF
Buffer	10mM Tris-HCI, 1mM EDTA, pH8.0
Warning	pORF-hDROSHA ORF Vector is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Storage	1 year when stored at -20°C or lower in a non-frost free freezer.

Target Gene

DROSHA

Background

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

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