Human DNA2 adenoviral particles

Name: Human DNA2 adenoviral particles
SKU: AD04941Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD04941Z

Storage : -80℃ Shipping : Frozen on dry ice

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD04941Z
Description	Adenovirus with ORF of DNA replication helicase 2 homolog (yeast) (DNA2).
Gene	DNA2
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	DNA2 DNA replication helicase 2 homolog (yeast) [ Homo sapiens ]
Gene Symbol	DNA2
Synonyms	DNA2; DNA replication helicase 2 homolog (yeast); DNA2 DNA replication helicase 2 like (yeast) , DNA2L; DNA2-like helicase; KIAA0083; DNA replication ATP-dependent helicase-like homolog; DNA2L; FLJ10063; MGC133297;
Gene ID	1763
Uni Prot ID	P51530
m RNA Refseq	BC111740
Chromosome Location	10q21.3-q22.1
Function	5-flap endonuclease activity; ATP binding; ATP-dependent DNA helicase activity; ATPase activity; DNA binding; helicase activity; hydrolase activity; nucleotide binding; site-specific endodeoxyribonuclease activity, specific for altered base;
Pathway	Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; DNA Replication, organism-specific biosystem; DNA replication, organism-specific biosystem; DNA replication, conserved biosystem; DNA strand elongation, organism-specific biosystem;
MIM	601810

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