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Human CDKN1A Knockdown Cell Line-HeLa

See other products for CDKN1A
Cat.No.
CSC-RK0280
Background
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
CDKN1A
Synonyms
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); CDKN1; cyclin-dependent kinase inhibitor 1; CAP20; CIP1; P21; p21CIP1; p21Cip1/Waf1; SDI1; WAF1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6; MDA-6;
Gene ID
MIM
UniProt ID
P38936
Chromosome Location
6p21.1
Pathway
AKT phosphorylates targets in the cytosol, organism-specific biosystem; AMPK signaling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Bladder cancer, organism-specific biosystem;
Function
cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase inhibitor activity; kinase activity; metal ion binding; protein binding; protein kinase inhibitor activity;
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CSC-DC002890
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Cat#
Product Name
Titer
Product Size
Species
Price
LV00232Z
10^7 - 10^9 copies/ml
200 ul
Human
AD03488Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human
Cat#
Product Name
Size/Form
Species
Price

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