Tel: 1-631-626-9181 (USA)   44-207-097-1828 (Europe)
  Email:

Human CDKN1A Knockdown Cell Line-HeLa

Cat.No.
CSC-RK0280
Abbr
HeLa-HuCDKN1A Knockdown
Alias
CDKN1A,CDKN1,CAP20,CIP1,P21,p21CIP1,SDI1,WAF1,MDA-6,
Growth Properties
Adherent
Host Cell
HeLa
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Quick Inquiry

   Please input "biogene" as verification code.