Human CDC73 adenoviral particles

Human CDC73 adenoviral particles are viral vectors engineered from adenovirus (a nonenveloped, double-stranded DNA virus). These particles are specifically designed to carry the CDC73 gene, which encodes parafibromin, a key tumor suppressor involved in cell cycle and transcriptional regulation. The adenoviral backbone is modified to be replication-defective, enhancing safety for both research and therapeutic applications. Due to the natural tropism of adenovirus for epithelial and hematopoietic lineages, these particles efficiently transduce a variety of human cells, including primary and dividing cells.

These adenoviral particles are powerful tools for basic research and clinical development. In functional genomics, they enable overexpression or rescue experiments to investigate the role of parafibromin in diseases such as hyperparathyroidism-jaw tumor (HPT-JT) syndrome, where CDC73 mutations are prevalent. Researchers are using these particles to study molecular pathways involved in Wnt/β-catenin signaling, histone modification, and cell proliferation. In gene therapy, CDC73 adenoviral particles are used to restore tumor suppressor function in cancers where CDC73 is deleted or inactivated, particularly parathyroid and renal cancers. Their high transduction efficiency makes them ideal for in vitro and in vivo models, including xenograft studies and organoid cultures.