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Human C14orf129 cDNA Clone(NM_016472.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG000440

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Product Information

Gene Information

Cat. No. CDFG000440
Product Type cDNA clone
Gene Abbr C14orf129
Species Human
ORF Size 2170bp
Size 10 ug
Vector pCMV6-XL5
Target Gene C14ORF129
Background This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
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