Human ATR Knockdown Cell Line-HeLa

Name: Human ATR Knockdown Cell Line-HeLa
SKU: CSC-RK0024
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0024

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0024
Target Gene	ATR
Abbr	HeLa-HuATR Knockdown
Alias	ATR, FRP1, MEC1, SCKL, SCKL1, FCTCS
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ATR ataxia telangiectasia and Rad3 related [ Homo sapiens ]
Gene Symbol	ATR
Synonyms	FRP1; MEC1; SCKL; FCTCS; SCKL1
Gene Description	ataxia telangiectasia and Rad3 related
Gene ID	545
Uni Prot ID	Q13535
m RNA Refseq	NM_001184.3
Protein Refseq	NP_001175.2
Chromosome Location	3q23
Function	ATP binding; DNA binding; MutLalpha complex binding; MutSalpha complex binding; protein binding; protein kinase activity; protein serine/threonine kinase activity;
Pathway	Activation of ATR in response to replication stress, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chromosome Maintenance, organism-specific biosystem;
MIM	601215

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The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

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