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Human ATR Knockdown Cell Line-HeLa

See other products for ATR
Cat.No.
CSC-RK0024
Background
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
ATR
Synonyms
ATR; ataxia telangiectasia and Rad3 related; serine/threonine-protein kinase ATR; FRP1; MEC1; mitosis entry checkpoint 1; homolog (S. cerevisiae); SCKL; SCKL1; protein kinase ATR; Rad3 related protein; FRAP-related protein 1; FRAP-related protein-1; MEC1, mitosis entry checkpoint 1, homolog; ataxia telangiectasia and Rad3-related protein; FCTCS;
Gene ID
MIM
UniProt ID
Q13535
Chromosome Location
3q22-q24
Pathway
Activation of ATR in response to replication stress, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chromosome Maintenance, organism-specific biosystem;
Function
ATP binding; DNA binding; MutLalpha complex binding; MutSalpha complex binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity;

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