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Human ATR Knockdown Cell Line-HeLa

Cat.No.
CSC-RK0024
Abbr
HeLa-HuATR Knockdown
Alias
ATR,FRP1,MEC1,SCKL,SCKL1,FCTCS,
Growth Properties
Adherent
Host Cell
HeLa
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

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