Human ARHGAP35 ORF clone (NM_004491.4)

Name: Human ARHGAP35 ORF clone (NM_004491.4)
SKU: CDCR029654
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR029654

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Product Information

Gene Information

Cat. No.	CDCR029654
Description	Homo sapiens Rho GTPase activating protein 35 (ARHGAP35), mRNA.
Product Type	ORF clone
Gene Abbr	ARHGAP35
Species	Human
ORF Size	4500
Format	purified plasmid or bacterial stock
Vector	pDONR

Target Gene

ARHGAP35

Background

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

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