Human AGO1 Insect Cell Lysate

Name: Human AGO1 Insect Cell Lysate
SKU: CLOE-0943
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CLOE-0943 Host Cell : Baculovirus-Insect cell

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Cell Lysate Information

Gene Information

Cat. No.	CLOE-0943
Introduction	This cell lysate over-expresses N-terminal polyhistidine tagged human AGO1 (NP_036331.1). Purification of target protein (s) from this cell lysate has been verified.
Target Gene	AGO1
Host Cell	Baculovirus-Insect cell
Applications	Positive control for Western Blot (WB), antibody verification, protein purification
Storage	Upon receipt, store at 4°C, or prepare aliquots and store at -80°C. Multiple freeze-thaw cycles should be avoided.
Shipping	Ice package

Target Gene

EIF2C1

Background

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

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