HINT1 Knockout Cell Line-HeLa

Name: HINT1 Knockout Cell Line-HeLa
SKU: CSC-RT0136

For research use only. Not intended for any clinical use.

Cat.No.

CSC-RT0136

Description

HeLa-HINT1 (-/-) is a stable cell line with a homozygous knockout of human HINT1

Background

This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015]

Growth Properties

Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO₂. Split at 80-90% confluence, approximately 1:4-1:6.

Host Cell

HeLa

Publications

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