GDF3 adenovirus

Growth differentiation factor 3 (GDF3), a member of the transforming growth factor β (TGF-β) superfamily, plays a crucial role in regulating cell growth, differentiation, and embryonic development. GDF3 is particularly well-known for its involvement in maintaining stem cell pluripotency and regulating the bone morphogenetic protein (BMP) signaling pathway. Studies have shown that GDF3 is highly expressed during early embryogenesis and is involved in the formation of mesoderm and endoderm tissues. In adult tissues, GDF3 expression is limited but is implicated in the regulation of adipose tissue and skeletal development.

The GDF3 adenovirus is a recombinant viral vector designed to efficiently deliver the GDF3 gene to target cells. Adenoviral vectors are widely used in gene therapy and research due to their high transduction efficiency, broad tropism, and ability to infect both dividing and non-dividing cells. GDF3 adenoviruses are typically constructed by inserting the GDF3 coding sequence into an adenoviral backbone, replacing viral genes essential for replication to ensure safety. Following infection, the adenovirus delivers the GDF3 gene to host cells, achieving transient but stable protein expression. This system is particularly useful for studying the biological functions of GDF3, including its effects on stem cell differentiation, tissue regeneration, and metabolic regulation. Furthermore, GDF3 adenovirus has potential therapeutic applications, such as promoting bone repair, regulating adipogenesis, and enhancing stem cell therapy.