CHGB adenovirus

The CHGB gene, also known as chromogranin B or secretogranin 1, encodes a secretory protein member of the granin family. These proteins are primarily located in secretory vesicles of neuroendocrine cells and neurons and play a key role in the storage, release, and processing of hormones and neurotransmitters. Chromogranin B is co-secreted with catecholamines, peptides, and other bioactive molecules as a prohormone that can be cleaved into smaller functional peptides, such as secretagogues with antimicrobial properties. CHGB is often used as a biomarker for neuroendocrine tumors and other secretory diseases because it is widely expressed in neuroendocrine tissues. In addition, it is involved in regulating the secretory pathway, making it an important target for studying cellular secretory mechanisms and related diseases.

The CHGB adenovirus is a recombinant adenoviral vector designed to deliver the CHGB gene or its regulatory elements to target cells for research or therapeutic purposes. Adenoviral vectors are widely used in gene therapy and molecular biology due to their high transduction efficiency, broad tropism, and ability to infect both dividing and non-dividing cells. The CHGB adenovirus enables researchers to overexpress or silence the CHGB gene in vitro or in vivo, thus facilitating the study of its biological functions, such as its role in secretory processes, neuroendocrine signaling, and disease pathogenesis. In addition, the vector can also be used in gene therapy strategies for neuroendocrine diseases or cancer to restore normal cell function or induce therapeutic effects by regulating CHGB expression.