CAPN10 adenovirus

The CAPN10 gene is located on chromosome 2q37.3 and encodes calpain 10, which belongs to the calcium-dependent cysteine protease family. This gene plays a crucial role in a variety of cellular processes, including insulin secretion, glucose metabolism, and apoptosis. Notably, CAPN10 has been extensively studied for its association with type 2 diabetes mellitus (T2DM), as specific single nucleotide polymorphisms (SNPs) in this gene have been associated with increased susceptibility to the disease. Calpain 10 is involved in signal transduction pathways, cytoskeletal remodeling, and mitochondrial function. Despite its significance, the precise molecular mechanisms by which CAPN10 affects glucose homeostasis are still under investigation, making it a promising target for genetic and functional studies.

The CAPN10 adenovirus is a recombinant viral vector designed to deliver the CAPN10 gene to target cells for research or therapeutic purposes. Adenoviral vectors are widely used in gene therapy and molecular biology due to their high transduction efficiency, broad tropism, and ability to infect both dividing and non-dividing cells. The CAPN10 adenovirus enables scientists to overexpress or modulate calpain-10 levels in vitro or in vivo, facilitating the study of its role in metabolic disorders, particularly diabetes. In addition, this tool can be used to explore potential gene therapy approaches to treat type 2 diabetes mellitus (T2DM) by restoring normal CAPN10 function in insulin-sensitive tissues.