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Cat.No. : CSC-RR01248 Host Cell: THP1
| Cat. No. | CSC-RR01248 |
| Description | THP1-ISRE-Luc cell line is engineered to express luciferase reporter gene under the control of ISRE (Interferon Stimulated Response Element). It is a useful cell model for studying the IRF3/ISRE signaling pathway in THP1 cells. |
| Gene | ISRE-Luc |
| Host Cell | THP1 |
| Host Cell Species | Homo sapiens (Human) |
| Stability | This cell line is stable at least 10 passages. |
| Product Type | Signaling Pathway Reporter Cell Lines |
| Applications | Used to monitor the activation of IFN (interferon)-stimulated signaling pathways via ISRE (IFN-stimulated response element); applicable for studying antiviral responses, IFN efficacy, or immune-modulatory compounds. |
| Size Form | One vial of frozen cells, typically >1x10^6cells/vial |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Suspension cell line |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
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This cell line is an exceptional tool for studying the JAK/STAT pathway. The ISRE-mediated luciferase activity showed a rapid and distinct response to IFN-alpha treatment. The background luminescence is low, allowing us to detect even subtle changes in the antiviral response.
United Kingdom
08/22/2023
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