INPP5D Alzheimer's Disease Risk Genotyping Kit

Name: INPP5D Alzheimer's Disease Risk Genotyping Kit
SKU: GK-0011
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : GK-0011

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Product Information

Cat. No.	GK-0011
Description	Leveraging two major technology platforms—KASP (Kompetitive Allele-Specific PCR) and TaqMan MGB probes—we provide cost-effective or ultra-high-specificity custom genotyping services for any species and any genetic locus.
Introduction	If the customer provides a specific genotyping RS number, we can perform custom development and offer SNP testing services upon receipt of mailed blood/tissue/cell samples. The customer needs to provide: 1. Sample materials such as cells (≥10^6 cells), tissue (≥300 mg), blood (≥1 ml), serum (≥1.5 ml), etc.; nucleic acid extraction is charged separately; 2. Genomic DNA (volume ≥30 μl, concentration ≥50 ng/μl), with purity OD260/280 between 1.7 and 1.9; 3. For the human genome, the RS number of the SNP locus must be provided. For other species without rs numbers, such as cattle, chickens, and fish, the exact 200 bp sequences flanking both upstream and downstream of the SNP locus must be provided, along with the mutation type at the SNP locus and whether any other linked loci exist within 25 bp upstream or downstream of the locus. We deliver: 1. SNP results (Excel spreadsheet); 2. Complete experimental report: amplification and reaction systems, primers involved, and probe sequences; Scatter plot of clustering results (KASP method) / Amplification curves and Ct value analysis (TaqMan MGB method). 3. Other relevant materials required by the customer.
Gene	INPP5D
Features	Genotyping Accuracy >99%
Applications	Research Use
Size	Box
Format	100T
Note	All SNP kits are custom-developed and not available from stock. Primers and probes are individually designed and synthesized based on the RS numbers or target sequences provided by the customer.
Storage	-20℃

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Functional variants of the INPP5D gene are an important genetic risk factor for Alzheimer's disease, regulating neuroinflammatory responses and Aβ clearance capacity by affecting microglial function. This kit detects two independently inherited functional SNP loci in the INPP5D gene, which respectively indicate increased disease risk and a protective effect, and can be combined with the APOE ε4 allele to construct a polygenic risk assessment model. As the strongest genetic risk factor, APOE ε4, together with INPP5D functional variants, synergistically reflects an individual's genetic susceptibility characteristics in neuroinflammatory regulation and amyloid metabolism, helping to identify high-risk populations early and providing a scientific basis for risk stratification, early intervention, and personalized health management of Alzheimer's disease.

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