GPX4 Oxidative Stress Genotyping Kit

Name: GPX4 Oxidative Stress Genotyping Kit
SKU: GK-0001
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : GK-0001

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Product Information

Cat. No.	GK-0001
Description	Leveraging two major technology platforms—KASP (Kompetitive Allele-Specific PCR) and TaqMan MGB probes—we provide cost-effective or ultra-high-specificity custom genotyping services for any species and any genetic locus.
Introduction	If the customer provides a specific genotyping RS number, we can perform custom development and offer SNP testing services upon receipt of mailed blood/tissue/cell samples. The customer needs to provide: 1. Sample materials such as cells (≥10^6 cells), tissue (≥300 mg), blood (≥1 ml), serum (≥1.5 ml), etc.; nucleic acid extraction is charged separately; 2. Genomic DNA (volume ≥30 μl, concentration ≥50 ng/μl), with purity OD260/280 between 1.7 and 1.9; 3. For the human genome, the RS number of the SNP locus must be provided. For other species without rs numbers, such as cattle, chickens, and fish, the exact 200 bp sequences flanking both upstream and downstream of the SNP locus must be provided, along with the mutation type at the SNP locus and whether any other linked loci exist within 25 bp upstream or downstream of the locus. We deliver: 1. SNP results (Excel spreadsheet); 2. Complete experimental report: amplification and reaction systems, primers involved, and probe sequences; Scatter plot of clustering results (KASP method) / Amplification curves and Ct value analysis (TaqMan MGB method). 3. Other relevant materials required by the customer.
Gene	GPX4
Features	Genotyping Accuracy >99%
Applications	Research Use
Size	Box
Format	100T
Note	All SNP kits are custom-developed and not available from stock. Primers and probes are individually designed and synthesized based on the RS numbers or target sequences provided by the customer.
Storage	-20℃

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The GPX4 gene encodes glutathione peroxidase 4, a core selenoprotein of the human antioxidant defense system responsible for clearing lipid peroxides, maintaining cell membrane integrity, and inhibiting ferroptosis. The C718T locus in its 3'-UTR region is the most extensively studied regulatory SNP, where the T allele reduces mRNA stability and decreases GPX4 expression, leading to elevated oxidative stress levels in the body. Numerous studies have confirmed that this locus is significantly associated with genetic susceptibility to various oxidative stress-related diseases such as stroke, coronary heart disease, type 2 diabetes, and gastric cancer, and exhibits an interaction effect with selenium nutritional status. This locus has become an important molecular marker for oxidative stress disease risk assessment, precision nutritional intervention, and individualized antioxidant therapy, with broad clinical application prospects and translational value in the fields of cardiovascular and cerebrovascular disease prevention, tumor risk prediction, and health management.

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