APOE Alzheimer's Disease Risk Genotyping Kit

Name: APOE Alzheimer's Disease Risk Genotyping Kit
SKU: GK-0004
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : GK-0004

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Product Information

Cat. No.	GK-0004
Description	Leveraging two major technology platforms—KASP (Kompetitive Allele-Specific PCR) and TaqMan MGB probes—we provide cost-effective or ultra-high-specificity custom genotyping services for any species and any genetic locus.
Introduction	If the customer provides a specific genotyping RS number, we can perform custom development and offer SNP testing services upon receipt of mailed blood/tissue/cell samples. The customer needs to provide: 1. Sample materials such as cells (≥10^6 cells), tissue (≥300 mg), blood (≥1 ml), serum (≥1.5 ml), etc.; nucleic acid extraction is charged separately; 2. Genomic DNA (volume ≥30 μl, concentration ≥50 ng/μl), with purity OD260/280 between 1.7 and 1.9; 3. For the human genome, the RS number of the SNP locus must be provided. For other species without rs numbers, such as cattle, chickens, and fish, the exact 200 bp sequences flanking both upstream and downstream of the SNP locus must be provided, along with the mutation type at the SNP locus and whether any other linked loci exist within 25 bp upstream or downstream of the locus. We deliver: 1. SNP results (Excel spreadsheet); 2. Complete experimental report: amplification and reaction systems, primers involved, and probe sequences; Scatter plot of clustering results (KASP method) / Amplification curves and Ct value analysis (TaqMan MGB method). 3. Other relevant materials required by the customer.
Gene	APOE
Features	Genotyping Accuracy >99%
Applications	Research Use
Size	Box
Format	100T
Note	All SNP kits are custom-developed and not available from stock. Primers and probes are individually designed and synthesized based on the RS numbers or target sequences provided by the customer.
Storage	-20℃

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The apolipoprotein E (APOE) gene is the most critical genetic risk factor for Alzheimer's disease (AD), profoundly influencing AD onset risk and disease progression through different combinations of its three alleles (ε2, ε3, ε4). Studies show that 71.5%-92.7% of AD cases can be attributed to the negative effects of the ε3 and ε4 alleles. Nucleotide variants at two key SNP loci respectively determine two amino acid substitutions, thereby forming the three protein isoforms ε2, ε3, and ε4; detection of these two loci has become the gold standard for APOE genotyping. The genotypes composed of the ε3 and ε4 alleles, such as ε3/ε4, together form a risk gradient; the ε4/ε4 genotype carries a 23- to 71-fold higher disease risk than ε2/ε2, where ε4 significantly increases disease risk and homozygotes have an onset age 10-15 years earlier, while ε2 exerts a significant protective effect (risk reduced by approximately 99%). This provides a core genetic basis for early AD risk screening, individualized treatment stratification, and prevention strategy development, and can be used for early risk stratification and precision prevention; APOE genotyping will play an increasingly important role in the early screening and precision management of Alzheimer's disease.

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