Panoply™ Human IRS1 Knockdown Stable Cell Line

Name: Panoply™ Human IRS1 Knockdown Stable Cell Line
SKU: CSC-DC007750
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC007750

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-DC007750
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	IRS1
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	IRS1 insulin receptor substrate 1 [ Homo sapiens ]
Gene Symbol	IRS1
Synonyms	HIRS-1
Gene Description	insulin receptor substrate 1
GeneID	3667
Uni ProtID	P35568
mRNA Refseq	NM_005544.2
Protein Refseq	NP_005535.1
Chromosome Location	2q36
Function	SH2 domain binding; insulin receptor binding; insulin-like growth factor receptor binding; insulin-like growth factor-activated receptor activity; phosphatidylinositol 3-kinase binding; phosphatidylinositol 3-kinase binding; phospholipid binding; protein binding; protein kinase C binding; signal transducer activity; transmembrane receptor protein tyrosine kinase adaptor activity;
Pathway	Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem;
MIM	147545

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