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Panoply™ Human HIF1AN Knockdown Stable Cell Line

Cat.No.
CSC-DC006988
Description
Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by RT-PCR. Cells are rigorously qualified and mycoplasma free.
Growth Properties
Adherent
Host Cell
HEK293 (Hela and other cell types are also available)
Morphology
Epithelial
Quality Control
Negative for bacteria, yeast, fungi and mycoplasma.
Shipping
Dry Ice
Size/Form
2 × 10^6 cells / vial
Species
Human
Storage
Liquid Nitrogen
Gene Information
Gene Symbol
HIF1AN
Synonyms
FIH1
Gene Description
hypoxia-inducible factor 1, alpha subunit inhibitor
Gene ID
UniProt ID
Q9NWT6
mRNA Refseq
Protein Refseq
Chromosome Location
10q24
Function
NF-kappaB binding; Notch binding; ankyrin repeat binding; carboxylic acid binding; cofactor binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; oxygen sensor activity; peptidyl-asparagine 3-dioxygenase activity; peptidyl-asparagine 3-dioxygenase activity; peptidyl-histidine dioxygenase activity; protein binding; protein homodimerization activity; zinc ion binding;
Pathway
Cellular response to hypoxia, organism-specific biosystem; Cellular responses to stress, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem; Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha, organism-specific biosystem; Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, organism-specific biosystem;
MIM

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