Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by RT-PCR. Cells are rigorously qualified and mycoplasma free.
HEK293 (Hela and other cell types are also available)
Negative for bacteria, yeast, fungi and mycoplasma.
Cellular response to hypoxia, organism-specific biosystem; Cellular responses to stress, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem; Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha, organism-specific biosystem; Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, organism-specific biosystem;
NF-kappaB binding; Notch binding; ankyrin repeat binding; carboxylic acid binding; cofactor binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; oxygen sensor activity; peptidyl-asparagine 3-dioxygenase activity; peptidyl-asparagine 3-dioxygenase activity; peptidyl-histidine dioxygenase activity; protein binding; protein homodimerization activity; zinc ion binding;