Luc/GFP Reporter Cell Line-CT26

High-dose radiation treatment may efficiently change the immunological microenvironment of mouse colon tumors, especially CT26 and MC38, producing complete remissions. Although the research reveals that a single radiation dosage of 30 Gy causes notable alterations, like enhanced CD8+ T cell infiltration and reduced myeloid-derived suppressor cells (MDSCs), these tumors are poorly immunogenic, which presents obstacles to therapy. The procedure generates a strong anti-tumor immune response driven by IFN-γ using antigen cross-presentation by CD8+ dendritic cells and the activity of CD4+ T cells.

Figure 1. The researchers transduced CT26 cells with a GFP-firefly luciferase fusion gene, enhancing transduction efficiency to create a stable cell line for tumor immune studies. (Filatenkov A, et al., 2015)

Creative Biogene's Luc/GFP Reporter Cell Line-CT26 product is designed for researchers exploring similar immune response dynamics in tumor studies. This stable cell line, engineered for bioluminescence and fluorescence, allows for real-time monitoring of tumor behavior and immune interactions in vivo.