Human hHR23A Knockdown Cell Line-HeLa

Name: Human hHR23A Knockdown Cell Line-HeLa
SKU: CSC-RK0005
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0005

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0005
Background	The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Target Gene	RAD23A
Abbr	HeLa-HuhHR23A Knockdown
Alias	RAD23A, RAD23, HR23A
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	RAD23A RAD23 homolog A (S. cerevisiae) [ Homo sapiens ]
Gene Symbol	RAD23A
Synonyms	RAD23A; RAD23 homolog A (S. cerevisiae); RAD23 (S. cerevisiae) homolog A; UV excision repair protein RAD23 homolog A; HHR23A; MGC111083; RAD23; yeast homolog; A; HR23A; RAD23, yeast homolog, A;
GeneID	5886
Uni ProtID	P54725
mRNA Refseq	BC014026
Chromosome Location	19p13.2
Function	damaged DNA binding; polyubiquitin binding; protein binding; single-stranded DNA binding;
Pathway	Nucleotide excision repair, organism-specific biosystem; Nucleotide excision repair, conserved biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem;
MIM	600061

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