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Human hHR23A Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0005
Background
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
RAD23A
Synonyms
RAD23A; RAD23 homolog A (S. cerevisiae); RAD23 (S. cerevisiae) homolog A; UV excision repair protein RAD23 homolog A; HHR23A; MGC111083; RAD23; yeast homolog; A; HR23A; RAD23, yeast homolog, A;
Gene ID
MIM
UniProt ID
P54725
Chromosome Location
19p13.2
Pathway
Nucleotide excision repair, organism-specific biosystem; Nucleotide excision repair, conserved biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem;
Function
damaged DNA binding; polyubiquitin binding; protein binding; single-stranded DNA binding;

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