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Human XRCC5 Knockdown Cell Line-LN428 Glioma

Cat.No.
CSC-RK0243
Abbr
LN428 Glioma-HuXRCC5 Knockdown
Alias
XRCC5,KARP 1,80kDa,KU80,Ku86,KUB2,TLAA,CTC85,CTCBF,NFIV,KARP1,KARP-1,FLJ39089,
Growth Properties
Adherent
Host Cell
LN428 glioma
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

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