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Human XRCC3 Knockdown Cell Line-LN428 Glioma

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Cat.No.
CSC-RK0249
Background
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
XRCC3
Synonyms
XRCC3; X-ray repair complementing defective repair in Chinese hamster cells 3; DNA repair protein XRCC3; RAD51 like; X-ray repair cross-complementing protein 3; CMM6;
Gene ID
MIM
UniProt ID
O43542
Chromosome Location
14q32.3
Pathway
Fluoropyrimidine Activity, organism-specific biosystem; Homologous recombination, organism-specific biosystem; Homologous recombination, conserved biosystem;
Function
ATP binding; DNA binding; DNA-dependent ATPase activity; nucleotide binding; protein binding;

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