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Human XRCC1 Knockdown Cell Line-LN428 Glioma

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Cat.No.
CSC-RK0225
Background
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
XRCC1
Synonyms
XRCC1; X-ray repair complementing defective repair in Chinese hamster cells 1; RCC; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster;
Gene ID
MIM
UniProt ID
P18887
Chromosome Location
19q13.2
Pathway
BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; DNA Repair, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem;
Function
damaged DNA binding; protein binding;

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