Human TXNRD2 Knockdown Cell Line-HeLa

Name: Human TXNRD2 Knockdown Cell Line-HeLa
SKU: CSC-RK0296
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0296

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0296
Background	Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.
Target Gene	TXNRD2
Abbr	HeLa-HuTXNRD2 Knockdown
Alias	TXNRD2, TR, TR3, TRXR2, SELZ, TR-BETA
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	TXNRD2 thioredoxin reductase 2 [ Homo sapiens ]
Gene Symbol	TXNRD2
Synonyms	TR; TR3; SELZ; TRXR2; TR-BETA
Gene Description	thioredoxin reductase 2
Gene ID	10587
Uni Prot ID	Q9NNW7
m RNA Refseq	NM_006440.3
Protein Refseq	NP_006431.2
Chromosome Location	22q11.21
Function	NADP binding; flavin adenine dinucleotide binding; protein binding; protein homodimerization activity; thioredoxin-disulfide reductase activity;
Pathway	Oxidative Stress, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, conserved biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenium Pathway, organism-specific biosystem; Selenocompound metabolism, organism-specific biosystem; Selenocompound metabolism, conserved biosystem;
MIM	606448

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