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Human SIRT5 Knockdown Cell Line-LN428 Glioma

Cat.No.
CSC-RK0238
Abbr
LN428 Glioma-HuSIRT5 Knockdown
Alias
SIRT5,SIR2L5,FLJ36950,
Growth Properties
Adherent
Host Cell
LN428 glioma
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

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