This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.
Signaling events mediated by HDAC Class I, organism-specific biosystem;
NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; hydrolase activity; metal ion binding; protein-malonyllysine demalonylase activity; protein-succinyllysine desuccinylase activity; zinc ion binding;