Human SIRT3 Knockdown Cell Line - Glioma

Name: Human SIRT3 Knockdown Cell Line - Glioma
SKU: CSC-RK0244
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0244

Host Cell : Glioma Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RK0244
Description	This cell line is engineered to stably express shRNA targeting human SIRT3.
Target Gene	SIRT3
Host Cell	Glioma
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Storage	Liquid nitrogen
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	SIRT3 sirtuin 3 [ Homo sapiens ]
Gene Symbol	SIRT3
Synonyms	SIR2L3
Gene Description	sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
Gene ID	23410
Uni Prot ID	Q9NTG7
m RNA Refseq	NM_001017524.2
Protein Refseq	NP_001017524.1
Chromosome Location	11p15.5
Function	NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; protein binding; zinc ion binding;
Pathway	Energy Metabolism, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem;
MIM	604481

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