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Human SEPT9 Knockdown Cell Line-HeLa

Cat.No.
CSC-RK0287
Abbr
HeLa-HuSEPT9 Knockdown
Alias
SEPT9,AF17q25,MSF,MSF1,NAPB,PNUTL4,SINT1,SeptD1,septin 9
Growth Properties
Adherent
Host Cell
HeLa
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
Septin-9 is a protein that in humans is encoded by the SEPT9 gene. SEPT9 has been shown to interact with SEPT2 and SEPT7. Along with AHNAK, eIF4E and S100A11, SEPT9 has been shown to be essential for pseudopod protrusion, tumor cell migration and invasion. The v2 region of the SEPT9 promoter has been shown to be methylated in colorectal cancer tissue compared with normal colonic mucosa. Using highly sensitive real time PCR assays, methylated SEPT9 was detected in the blood of colorectal cancer patients. This alternate methylation pattern in cancer samples is suggestive of an aberrant activation or repression of the gene compared to normal tissue samples

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