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Human SEPT9 Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0287
Background
Septin-9 is a protein that in humans is encoded by the SEPT9 gene. SEPT9 has been shown to interact with SEPT2 and SEPT7. Along with AHNAK, eIF4E and S100A11, SEPT9 has been shown to be essential for pseudopod protrusion, tumor cell migration and invasion. The v2 region of the SEPT9 promoter has been shown to be methylated in colorectal cancer tissue compared with normal colonic mucosa. Using highly sensitive real time PCR assays, methylated SEPT9 was detected in the blood of colorectal cancer patients. This alternate methylation pattern in cancer samples is suggestive of an aberrant activation or repression of the gene compared to normal tissue samples
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
SEPT9
Synonyms
SEPT9; AF17q25; MSF; MSF1; NAPB; PNUTL4; SINT1; SeptD1; MLL septin-like fusion protein MSF-A; Ov/Br septin; ovarian/breast septin; septin D1; septin-9; septin 9
Gene ID
MIM
UniProt ID
Q9UHD8
Chromosome Location
17q25
Pathway
GTP catabolic process; cell cycle; cell division; protein heterooligomerization
Function
GTP binding; GTPase activity; protein binding

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