Human RHOQ Knockdown Cell Line-HeLa

Name: Human RHOQ Knockdown Cell Line-HeLa
SKU: CSC-RK0286
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0286

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RK0286
Target Gene	RHOQ
Abbr	HeLa-HuRHOQ Knockdown
Alias	RHOQ, TC10, ARHQ, TC10A, RASL7A
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	RHOQ ras homolog family member Q [ Homo sapiens ]
Gene Symbol	RHOQ
Synonyms	ARHQ; TC10; TC10A; RASL7A
Gene Description	ras homolog gene family, member Q
Gene ID	23433
Uni Prot ID	P17081
m RNA Refseq	NM_012249.3
Protein Refseq	NP_036381.2
Chromosome Location	2p21
Pathway	Insulin Pathway, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; Insulin signaling pathway, organism-specific biosystem; Insulin signaling pathway, conserved biosystem; Insulin-mediated glucose transport, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem;
MIM	605857

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This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14.

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