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Human RHOQ Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0286
Background
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
RHOQ
Synonyms
RHOQ; ras homolog family member Q; ARHQ, ras homolog gene family, member Q , RAS like, family 7, member A , RASL7A; rho-related GTP-binding protein RhoQ; TC10; ras-like protein TC10; RAS-like, family 7, member A; ras homolog gene family, member Q; ras-like protein family member 7A; ARHQ; TC10A; RASL7A;
Gene ID
MIM
UniProt ID
P17081
Chromosome Location
2p21
Pathway
Insulin Pathway, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; Insulin signaling pathway, organism-specific biosystem; Insulin signaling pathway, conserved biosystem; Insulin-mediated glucose transport, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function
GBD domain binding; GTP binding; GTPase activity; nucleotide binding; profilin binding;

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