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Human PRKCA Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0282
Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
PRKCA
Synonyms
PRKCA; protein kinase C, alpha; PKCA; protein kinase C alpha type; PKC-A; aging-associated gene 6; AAG6; PRKACA; PKC-alpha; MGC129900; MGC129901;
Gene ID
MIM
UniProt ID
P17252
Chromosome Location
17q22-q24
Pathway
ATF-2 transcription factor network, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Amoebiasis, organism-specific biosystem;
Function
ATP binding; enzyme binding; histone kinase activity (H3-T6 specific); metal ion binding; nucleotide binding; protein binding; protein kinase C activity; protein kinase activity; protein kinase activity; protein serine/threonine kinase activity; zinc ion binding;

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