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Human NTHL1 Knockdown Cell Line-LN428 Glioma

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Cat.No.
CSC-RK0215
Background
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
NTHL1
Synonyms
NTHL1; nth endonuclease III-like 1 (E. coli); nth (E.coli endonuclease III) like 1; endonuclease III-like protein 1; NTH1; OCTS3;
Gene ID
MIM
UniProt ID
P78549
Chromosome Location
16p13.3
Pathway
Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; Cleavage of the damaged pyrimidine, organism-specific biosystem; DNA Repair, organism-specific biosystem;
Function
4 iron, 4 sulfur cluster binding; DNA N-glycosylase activity; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; double-stranded DNA binding; endonuclease activity; hydrolase activity, acting on glycosyl bonds; lyase activity; metal ion binding; protein binding;

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