Human NF1 Knockdown Cell Line-HeLa

Name: Human NF1 Knockdown Cell Line-HeLa
SKU: CSC-RK0276
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0276

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0276
Background	This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
Target Gene	NF1
Abbr	HeLa-HuNF1 Knockdown
Alias	NF1, WSS, NFNS, VRNF, FLJ21220, DKFZp686J1293
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	NF1 neurofibromin 1 [ Homo sapiens ]
Gene Symbol	NF1
Synonyms	WSS; NFNS; VRNF
Gene ID	4763
Uni Prot ID	P21359
m RNA Refseq	NM_000267.3
Protein Refseq	NP_000258.1
Chromosome Location	17q11.2
Function	Ras GTPase activator activity; protein binding;
Pathway	ATF-2 transcription factor network, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Integrated Breast Cancer Pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Signaling Pathways in Glioblastoma, organism-specific biosystem;
MIM	613113

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