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Human NF1 Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0276
Background
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
NF1
Synonyms
NF1; neurofibromin 1; neurofibromin; neurofibromatosis; von Recklinghausen disease; Watson disease; neurofibromatosis-related protein NF-1; WSS; NFNS; VRNF; FLJ21220; DKFZp686J1293;
Gene ID
MIM
UniProt ID
P21359
Chromosome Location
17q11.2
Pathway
ATF-2 transcription factor network, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Syndecan-2-mediated signaling events, organism-specific biosystem;
Function
Ras GTPase activator activity; protein binding;

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