The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.
ATP binding; DNA-dependent ATPase activity; Y-form DNA binding; centromeric DNA binding; damaged DNA binding; contributes_to dinucleotide insertion or deletion binding; contributes_to dinucleotide repeat insertion binding; double-strand/single-strand DNA junction binding; enzyme binding; NOT guanine/thymine mispair binding; loop DNA binding; contributes_to mismatched DNA binding; nucleotide binding; NOT contributes_to oxidized purine DNA binding; protein binding; NOT protein homodimerization activity; contributes_to single guanine insertion binding; contributes_to single-stranded DNA binding;