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Human MSH3 Knockdown Cell Line-LN428 Glioma

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Cat.No.
CSC-RK0234
Background
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
MSH3
Synonyms
MSH3; mutS homolog 3 (E. coli); mutS (E. coli) homolog 3; DNA mismatch repair protein Msh3; Divergent upstream protein; DUP; Mismatch repair protein 1; MRP1; hMSH3; mismatch repair protein 1; divergent upstream protein; MGC163306; MGC163308;
Gene ID
MIM
UniProt ID
P20585
Chromosome Location
5q11-q12
Pathway
Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Mismatch repair, organism-specific biosystem; Mismatch repair, conserved biosystem; Pathways in cancer, organism-specific biosystem;
Function
ATP binding; DNA-dependent ATPase activity; Y-form DNA binding; centromeric DNA binding; damaged DNA binding; contributes_to dinucleotide insertion or deletion binding; contributes_to dinucleotide repeat insertion binding; double-strand/single-strand DNA junction binding; enzyme binding; NOT guanine/thymine mispair binding; loop DNA binding; contributes_to mismatched DNA binding; nucleotide binding; NOT contributes_to oxidized purine DNA binding; protein binding; NOT protein homodimerization activity; contributes_to single guanine insertion binding; contributes_to single-stranded DNA binding;

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