Human MSH3 Knockdown Cell Line - Glioma

Name: Human MSH3 Knockdown Cell Line - Glioma
SKU: CSC-RK0234
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0234

Host Cell : Glioma Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0234
Description	This cell line is engineered to stably express shRNA targeting human MSH3.
Target Gene	MSH3
Host Cell	Glioma
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Storage	Liquid nitrogen
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	MSH3 mutS homolog 3 (E. coli) [ Homo sapiens ]
Gene Symbol	MSH3
Synonyms	MSH3; mutS homolog 3 (E. coli); mutS (E. coli) homolog 3; DNA mismatch repair protein Msh3; Divergent upstream protein; DUP; Mismatch repair protein 1; MRP1; hMSH3; mismatch repair protein 1; divergent upstream protein; MGC163306; MGC163308;
GeneID	4437
Uni ProtID	P20585
mRNA Refseq	BC130436
Chromosome Location	5q11-q12
Function	ATP binding; DNA-dependent ATPase activity; Y-form DNA binding; centromeric DNA binding; damaged DNA binding; contributes_to dinucleotide insertion or deletion binding; contributes_to dinucleotide repeat insertion binding; double-strand/single-strand DNA junction binding; enzyme binding; NOT guanine/thymine mispair binding; loop DNA binding; contributes_to mismatched DNA binding; nucleotide binding; NOT contributes_to oxidized purine DNA binding; protein binding;
Pathway	Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Mismatch repair, organism-specific biosystem; Mismatch repair, conserved biosystem; Pathways in cancer, organism-specific biosystem;
MIM	600887

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