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Human MSH3 Knockdown Cell Line-LN428 Glioma

Cat.No.
CSC-RK0234
Abbr
LN428 Glioma-HuMSH3 Knockdown
Alias
MSH3,DUP,MRP1,hMSH3,mismatch repair protein 1,MGC163306,MGC163308,
Growth Properties
Adherent
Host Cell
LN428 glioma
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.

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