DNA repair pathways usually maintain the integrity of the genome, thereby reducing the onset of cancer, disease and aging phenotypes. Conversely, the requirement for DNA repair and genome maintenance in response to radiation and genotoxic chemotherapeutics, implicates DNA repair proteins as prime targets for improving responses to currently employed anti-cancer regimens. Further, cancer-specific DNA repair defects offer novel approaches for tumor selective therapy. There are over 150 human proteins with functional roles in DNA repair. These fall into 14 general categories, including the classical DNA Repair pathways of Base Excision Repair (BER), Direct Reversal of Damage, Mismatch Excision Repair (MMR), Nucleotide Excision Repair (NER), Homologous Recombination (HR), Non-Homologous End-Joining (NHEJ) and the Fanconi Anemia/DNA crosslink repair pathway, plus proteins that modulate nucleotide pools, DNA polymerases, editing and processing nucleases.
MPG; N-methylpurine-DNA glycosylase; DNA-3-methyladenine glycosylase; alkyladenine DNA glycosylase; MDG; 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; proliferation-inducing protein 11; proliferation-inducing protein 16; N-methylpurine-DNA glycosylase, MPG; CRA36.1 (3-methyl-adenine DNA glycosylase); 3 end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p; AAG; ADPG; APNG; Mid1; anpg; PIG11; PIG16; CRA36.1;
Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; Cleavage of the damaged purine, organism-specific biosystem; DNA Repair, organism-specific biosystem;
DNA binding; DNA-3-methyladenine glycosylase activity; DNA-3-methylguanine glycosylase activity; DNA-7-methyladenine glycosylase activity; DNA-7-methylguanine glycosylase activity; alkylbase DNA N-glycosylase activity; catalytic activity; damaged DNA binding; hydrolase activity; protein binding;