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Human MLH3 Knockdown Cell Line-LN428 Glioma

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Cat.No.
CSC-RK0233
Background
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
MLH3
Synonyms
MLH3; mutL homolog 3 (E. coli); mutL (E. coli) homolog 3; DNA mismatch repair protein Mlh3; mutL protein homolog 3; HNPCC7; MGC138372;
Gene ID
MIM
UniProt ID
Q9UHC1
Chromosome Location
14q24.3
Pathway
Meiosis, organism-specific biosystem; Meiotic Recombination, organism-specific biosystem; Mismatch repair, organism-specific biosystem; Mismatch repair, conserved biosystem;
Function
ATP binding; ATPase activity; centromeric DNA binding; chromatin binding; mismatched DNA binding; mismatched DNA binding; protein binding; satellite DNA binding;

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