Human GNAQ Knockdown Cell Line-HeLa

Name: Human GNAQ Knockdown Cell Line-HeLa
SKU: CSC-RK0271
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0271

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0271
Background	This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.
Target Gene	GNAQ
Abbr	HeLa-HuGNAQ Knockdown
Alias	GNAQ, G ALPHA q, GAQ, G-ALPHA-q
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	GNAQ guanine nucleotide binding protein (G protein), q polypeptide [ Homo sapiens ]
Gene Symbol	GNAQ
Synonyms	GNAQ; guanine nucleotide binding protein (G protein), q polypeptide; guanine nucleotide-binding protein G(q) subunit alpha; G ALPHA q; GAQ; guanine nucleotide-binding protein alpha-q; G-ALPHA-q;
GeneID	2776
Uni ProtID	P50148
mRNA Refseq	BC057777
Chromosome Location	9q21
Function	G-protein beta/gamma-subunit complex binding; G-protein coupled receptor binding; GTP binding; GTPase activator activity; GTPase activity; guanyl nucleotide binding; guanyl-nucleotide exchange factor activity; metal ion binding; nucleotide binding; phospholipase C activity; protein binding; signal transducer activity;
Pathway	ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem;
MIM	600998

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