Human ELAVL1 Knockdown Cell Line-HeLa

Name: Human ELAVL1 Knockdown Cell Line-HeLa
SKU: CSC-RK0275
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0275

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0275
Background	The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.
Target Gene	ELAVL1
Abbr	HeLa-HuELAVL1 Knockdown
Alias	ELAVL1, Hua, HuR, MelG, ELAV1
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) [ Homo sapiens ]
Gene Symbol	ELAVL1
Synonyms	HUR; Hua; MelG; ELAV1
Gene Description	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
Gene ID	1994
Uni Prot ID	Q15717
m RNA Refseq	NM_001419.2
Protein Refseq	NP_001410.2
Chromosome Location	19p13.2
Function	AU-rich element binding; RNA binding; mRNA binding; nucleotide binding; protein binding; protein kinase binding;
Pathway	AMPK signaling, organism-specific biosystem; Gene Expression, organism-specific biosystem; Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystem; Stabilization of mRNA by HuR, organism-specific biosystem;
MIM	603466

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