Human EIF2C2 Knockdown Cell Line-HeLa

Name: Human EIF2C2 Knockdown Cell Line-HeLa
SKU: CSC-RK0256
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0256

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0256
Background	This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene.
Target Gene	EIF2C2
Abbr	HeLa-HuEIF2C2 Knockdown
Alias	EIF2C2, AGO2, argonaute 2, Q10, PPD, hAgo2, eIF2C 2, eIF-2C 2, argonaute2, MGC3183
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	EIF2C2 eukaryotic translation initiation factor 2C, 2 [ Homo sapiens ]
Gene Symbol	EIF2C2
Synonyms	EIF2C2; eukaryotic translation initiation factor 2C, 2; protein argonaute-2; AGO2; argonaute 2; Q10; PPD; hAgo2; eIF2C 2; eIF-2C 2; argonaute2; protein slicer; PAZ Piwi domain protein; MGC3183;
Gene ID	27161
Uni Prot ID	Q9UKV8
m RNA Refseq	BC018727
Chromosome Location	8q24
Function	RNA 7-methylguanosine cap binding; endonuclease activity; endoribonuclease activity, cleaving siRNA-paired mRNA; hydrolase activity; metal ion binding; protein binding; siRNA binding; contributes_to siRNA binding; translation initiation factor activity;
Pathway	Gene Expression, organism-specific biosystem; MicroRNA (miRNA) Biogenesis, organism-specific biosystem; Post-transcriptional Silencing By Small RNAs, organism-specific biosystem; Pre-NOTCH Expression and Processing, organism-specific biosystem; Pre-NOTCH Transcription and Translation, organism-specific biosystem; Regulatory RNA pathways, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
MIM	606229

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