Human DIABLO Knockdown Cell Line-HeLa

Name: Human DIABLO Knockdown Cell Line-HeLa
SKU: CSC-RK0266
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0266

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RK0266
Background	This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
Target Gene	DIABLO
Abbr	HeLa-HuDIABLO Knockdown
Alias	DIABLO, DFNA64, DIABLO S, FLJ10537, FLJ25049, SMAC, 0610041G12Rik, SMAC3, DIABLO-S
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	Homo sapiens diablo homolog (Drosophila), nuclear gene encoding mitochondrial protein, transcript variant 1 DNA.
Gene Symbol	DIABLO
Synonyms	SMAC, SMAC3, DIABLO-S, FLJ10537, FLJ25049
m RNA Refseq	NM_019887.3

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