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Human DIABLO Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0266
Background
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
DIABLO
Synonyms
DIABLO; diablo, IAP-binding mitochondrial protein; diablo homolog, mitochondrial; DFNA64; DIABLO S; FLJ10537; FLJ25049; second mitochondria derived activator of caspase; SMAC; 0610041G12Rik; mitochondrial Smac protein; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase; SMAC3; DIABLO-S;
Gene ID
MIM
UniProt ID
Q9NR28
Chromosome Location
12q24.31
Pathway
Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic factor-mediated response, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Intrinsic Pathway for Apoptosis, organism-specific biosystem; Release of apoptotic factors from the mitochondria, organism-specific biosystem; SMAC binds to IAPs, organism-specific biosystem;
Function
protein binding;

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