Human BTG2 Knockdown Cell Line-HeLa

Name: Human BTG2 Knockdown Cell Line-HeLa
SKU: CSC-RK0259
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0259

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0259
Target Gene	BTG2
Abbr	HeLa-HuBTG2 Knockdown
Alias	BTG2, MGC126063, MGC126064, PC3, TIS21
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	BTG2 BTG family, member 2 [ Homo sapiens ]
Gene Symbol	BTG2
Synonyms	PC3; TIS21
Gene Description	BTG family, member 2
Gene ID	7832
Uni Prot ID	P78543
m RNA Refseq	NM_006763.2
Protein Refseq	NP_006754.1
Chromosome Location	1q32
Function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; protein binding;
Pathway	Direct p53 effectors, organism-specific biosystem; RNA degradation, organism-specific biosystem; RNA degradation, conserved biosystem;
MIM	601597

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Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene (B-cell translocation gene 2) and in other mammals by the homologous Btg2 gene. This protein controls cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors.
The protein BTG2 is the human homolog of the PC3 (pheochromocytoma cell 3) protein in rat and of the Tis21 (tetradecanoyl phorbol acetate-inducible sequence 21) protein in mouse. Tis21 had been originally isolated as a sequence induced by TPA in mouse fibroblasts, whereas PC3 was originally isolated as sequence induced at the beginning of neuron differentiation; BTG2 was then isolated in human cells as sequence induced by p53 and DNA damage.

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